Resident Evil Requiem Final Puzzle Solution

Alexa Hunter

May 13, 2026

The Resident Evil Requiem final puzzle is one of the most hidden and rewarding challenges in the entire game. It’s not needed for the main story or any trophies, but cracking it gives you a massive 20,000 Challenge Points and a satisfying “aha” moment that ties together some of the creepiest lore in Resident Evil 9. I spent way too many hours on my first playthrough missing every clue, and even after finishing the game I had to dig through notes, item descriptions, and a second run just to figure it out.

In this guide, you’ll learn exactly how to solve the Resident Evil Requiem final puzzle solution from start to finish, with every step broken down so you don’t waste time. If you’re after a fresh copy of popular titles like this one, Lootbar is worth a quick visit for Steam Keys.

What Makes the Resident Evil Requiem Final Puzzle So Tricky?

The puzzle is called “Let the sweet pair hear the voice” in the challenge menu, and it only appears after you beat the game once. It revolves around two little girls from the Care Center experiments—Emily and Marie—and a creepy doll that acts as Marie’s stand-in. The “voice” is the child’s laughter you hear over the intercom when everything lines up.

Unlike normal RE9 puzzles that use obvious items or notes lying around, this one stretches across two full playthroughs as Grace Ashcroft. You have to set up conditions in the first run, carry over a key item, then trigger everything perfectly in the second. I remember reloading saves more times than I care to admit before I nailed it.

RE9 Final Puzzle Prerequisites Before You Even Start

You can’t finish this in one run, so plan ahead:

Beat the game at least once so the challenge unlocks and items carry over via the item box.
Play on any difficulty—story mode works fine if you just want the points.
Keep Marie’s Doll safe in your item box after the first playthrough.
Be ready to hold Emily in your arms during the final step.

Full Step-by-Step Guide to the Resident Evil Requiem Final Puzzle Solution

Here’s the exact order that works every time. I tested it myself on a fresh save to make sure.

First Playthrough – Set Everything Up

1. In the Care Center Basement, reach the Processing room with the conveyor belts and grinder. Don’t drain the pool right away. Wait (it takes about 15-20 real minutes) until 115 loose bodies drop into the bloody water. You’ll know it worked when the prompt says “a ton of blood flowed out” after you drain it.

2. Climb down, survive the grinder section without killing any zombies yourself—shoot their legs to stun them and let the machine finish the job.

3. After escaping the basement with Emily, head to the West Wing restroom (in the corridor between the kitchen and dining room). Carry Emily if you want, then flush the same toilet exactly eight times in a row. No popup appears, but it’s required.

4. Continue through the Courtyard and VIP Suite into the underground Research Facility. During the self-destruct sequence, after the blood tank explodes in the Collection & Testing room, look left near the metallic stairs in the blood on the floor.

5. Grab Marie’s Doll and keep it in your inventory or item box until you finish the game.

Complete the playthrough (releasing Elpis is fine) so the doll carries over.

Second Playthrough – Trigger the Final Step

6. Progress until you escape the Care Center Basement again after the elevator fight with “The Girl.” Pick up the Severed Hand that drops right after.

7. Take the Severed Hand to any Laser Microscope (East Wing Blood Lab or West Wing Office) and scan it. Solve the little DNA puzzle to reveal the message “Let’s play” plus the sequence GGC-AAG-AUA-ACG-UGU-CAU.

8. Grab Emily so you’re carrying her, then pull Marie’s Doll out of the item box.

9. Head straight to the Lead Researcher’s Office on the second floor of the Care Center East Wing. Interact with the puzzle box (the same one that once held the Star Quartz).

How to Decode and Enter the Exact RE9 Final Puzle Code

The RNA sequence looks random until you break it down:

Remove every “A” → GGC GUC GUG UCU
Match the letters using clues scattered around the game:
- G = Sun (sticker on the microscope)
- U = Moon (hidden on the Hourglass in the VIP Suite)
- C = Star (in Grace’s Blood Analysis Report in the Research Lab)

That gives you:

GGC = Sun, Sun, Star
GUC = Sun, Moon, Star
GUG = Sun, Moon, Sun
UCU = Moon, Star, Moon

Enter the full sequence while holding Emily and with Marie’s Doll in your inventory:

Sun, Sun, Star – Sun, Moon, Star – Sun, Moon, Sun – Moon, Star, Moon

You’ll immediately hear a little girl laugh over the intercom. If you did everything right, the game pops up the message that you “let the sweet pair hear the voice” and awards the 20,000 CP.

Common Mistakes That Waste Hours

Skipping the 115-body wait or killing zombies in the grinder yourself (the blood prompt will say “a lot” instead of “a ton”).
Forgetting to flush the toilet eight times.
Entering the code without both Emily in your arms and the doll in your inventory.
Trying to do it all in one playthrough—the doll simply won’t appear without the first-run setup.

Wrapping Up Resident Evil Requiem Final Puzzle Guide

Solving the Resident Evil Requiem final puzzle is pure survival-horror detective work, and once you pull it off you’ll feel like a true RE veteran. The steps might seem spread out, but they all make sense when you see how the clues tie together.

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